Research Blog
Peptide Research: Testing, Stability & Methods
Cited, educational articles on peptide chemistry, HPLC and mass spec testing, stability, storage and research methods. For research use only.
CompoundsPhoto: Nadine90 / Wikimedia Commons, CC BY-SA 3.0
Compound Profiles CJC-1295 and Ipamorelin: Two Receptor Pathways in One Research Blend
A GHRH receptor analogue and a ghrelin receptor agonist in one vial: the pharmacology behind the pairing, the design pitfalls of blends, and how they are tested.
DODaniel Okafor~4 min read
CompoundsPhoto: kaibara87 / Wikimedia Commons, CC BY 2.0
Compound Profiles Ipamorelin: A Selective Ghrelin Receptor Agonist Pentapeptide
How a five-residue GHRP derivative with three unnatural amino acids became the first selective ghrelin receptor agonist in animal and pituitary cell studies.
DODaniel Okafor~4 min read
CompoundsPhoto: kaibara87 / Wikimedia Commons, CC BY 2.0
Compound Profiles Sermorelin: GHRH(1-29) and the Minimal Active Fragment
Why the 29-residue N-terminal fragment of GHRH keeps the full hormone's activity, why it is short-lived, and how it became the template for later GHRH analogues.
DODaniel Okafor~5 min read
CompoundsPhoto: kaibara87 / Wikimedia Commons, CC BY 2.0
Compound Profiles Tesamorelin: A Stabilized GHRH(1-44) Analogue
How an N-terminal hexenoyl cap turns full-length GHRH(1-44) into a DPP-4 resistant analogue, and how tesamorelin compares structurally with sermorelin.
DODaniel Okafor~6 min read
CompoundsPhoto: Masur / Wikimedia Commons, CC BY-SA 3.0
Compound Profiles IGF-1 LR3: Structure of a Long-Acting IGF-1 Analogue
IGF-1 LR3 adds a 13-residue extension and an Arg3 substitution to IGF-1, reducing IGFBP binding. Its structure, signalling and analysis explained.
DODaniel Okafor~5 min read
Compounds
Compound Profiles AOD-9604: A Modified Growth Hormone Fragment (hGH 176-191)
AOD-9604 is a 16-residue C-terminal growth hormone fragment with an added tyrosine. Its sequence, disulfide loop, reported pharmacology and analysis.
DODaniel Okafor~5 min read
Compounds
Compound Profiles 5-Amino-1MQ: An NNMT Inhibitor Used in Research
5-Amino-1MQ is a quinolinium small molecule, not a peptide, studied as an inhibitor of NNMT at the junction of NAD+ salvage and methylation.
EMElena Marsh~5 min read
Compounds
Compound Profiles NAD+ in Research: Is NAD+ a Peptide?
NAD+ is sold beside peptides but is a dinucleotide coenzyme. Its structure, redox chemistry, consuming enzymes, salvage pathway and handling explained.
EMElena Marsh~6 min read
Compounds
Compound Profiles SS-31 (Elamipretide): A Cardiolipin-Targeting Tetrapeptide
SS-31 is a four-residue aromatic-cationic peptide studied for its association with cardiolipin at the inner mitochondrial membrane in in vitro systems.
DODaniel Okafor~5 min read
Educational content for research use only. Not for human consumption. Nothing here is medical advice or a claim about safety or efficacy.