Research Blog
TIRZ-2 Research Articles
3 articles on TIRZ-2: structure, receptor pharmacology, published findings, analytical testing and laboratory handling.
CompoundsPhoto: Habin Zhang / Wikimedia Commons
Compound Profiles Tirzepatide (TIRZ-2): Structure and Dual GIP/GLP-1 Receptor Pharmacology
A 39-residue GIP-based peptide with two Aib residues and a C20 diacid: how tirzepatide engages GIP and GLP-1 receptors, and what in vitro work shows.
DODaniel Okafor~5 min read
MechanismsPhoto: Habin Zhang / Wikimedia Commons
Mechanisms and Pharmacology Binding Affinity Explained: Kd, Ki, IC50 and EC50
What Kd, Ki, IC50 and EC50 actually measure, why affinity is not potency, and how to compare peptides acting at more than one receptor.
DODaniel Okafor~5 min read
MechanismsPhoto: Habin Zhang / Wikimedia Commons
Mechanisms and Pharmacology Retatrutide vs Tirzepatide vs Semaglutide: Receptor Pharmacology Compared
Mono, dual and triple agonists side by side: which receptors each peptide activates, how the structures differ, and how to compare them fairly in cell assays.
DODaniel Okafor~4 min read
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