Research Blog
Peptide Synthesis
How research peptides are made: solid-phase synthesis, Fmoc chemistry, protecting groups and coupling, cleavage and purification, and common peptide modifications.
Synthesis
Peptide Synthesis Peptide Synthesis: How Research Peptides Are Made
A practical overview of how research peptides are made, from protecting groups and coupling chemistry to cleavage, purification and release testing.
EMElena Marsh~6 min read
SynthesisPhoto: Gannu03 / Wikimedia Commons
Peptide Synthesis Solid-Phase Peptide Synthesis (SPPS) Explained
How SPPS works, from Merrifield's resin-bound chain to modern automated synthesizers, and why some peptide sequences remain difficult to assemble.
EMElena Marsh~5 min read
SynthesisPhoto: Lilly_M / Wikimedia Commons, CC BY-SA 3.0
Peptide Synthesis Fmoc Chemistry in Peptide Synthesis: Fmoc vs Boc
How the Fmoc group works, how Fmoc/tBu compares with Boc/Bzl chemistry, and how coupling choices show up as impurities in analytical data.
EMElena Marsh~5 min read
SynthesisPhoto: Nadine90 / Wikimedia Commons, CC BY-SA 3.0
Peptide Synthesis Peptide Purification: Cleavage, Prep HPLC and Salt Forms
From cleavage cocktail to dried powder: how crude synthetic peptides are purified by preparative HPLC, converted between salt forms and released.
EMElena Marsh~5 min read
Synthesis
Peptide Synthesis Custom Peptide Synthesis and Common Peptide Modifications
How to specify a custom peptide, what acetylation, amidation, cyclization and lipidation do chemically, and what drives cost and lead time.
EMElena Marsh~5 min read
Educational content for research use only. Not for human consumption. Nothing here is medical advice or a claim about safety or efficacy.